Homa-adiponectin index as useful surrogate marker in the screeening of insulin resistance

Results For the IR assessed by the clamp, the HOMA-AD demonstrated a stronger coefficient of correlation (r=0.64) compared with the HOMA-IR (r=-0.56); p<0.0001. In the ROC analysis, compared with the HOMA-IR, the HOMA-AD showed higher values of the AUC for the identification of IR based on the clamp test (AUC: 0.844 vs. AUC: 0.804) and on the metabolic syndrome (AUC: 0.703 vs. AUC: 0.689), respectively; p<0.001 for all. However, the pairwise comparison did not suggest superiority for the HOMA-AD in the diagnostic of IR (p>0.05). The optimal cutoff identified for the HOMA-AD for the diagnosis of IR was 0.51.